The GSX1 Polyclonal Antibody (PAC05398) is a valuable tool for researchers studying GSX1, a transcription factor involved in regulating gene expression and development. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting GSX1 in various biological samples, particularly in Western blot applications. By targeting the GSX1 protein, researchers can investigate its role in cellular processes and potentially uncover its significance in disease pathology.
GSX1, also known as GS homeobox 1, is known to play a crucial role in embryonic development, particularly in the central nervous system. Its involvement in neuronal differentiation and migration makes it a key player in brain development, making it a promising target for neurodevelopmental and neurodegenerative disorder research. By studying the functions of GSX1, researchers can gain insights into its potential therapeutic implications in neurological diseases.
Antibody Name:
GSX1 Antibody (PACO53998)
Antibody SKU:
PACO53998
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human GS homeobox 1 protein (67-147AA)
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO53998 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO53998 at dilution of 1:100.
Background:
Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.
Synonyms:
GS homeobox 1 (Homeobox protein GSH-1), GSX1, GSH1
UniProt Protein Function:
GSX1: Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development. Belongs to the Antp homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 13q12.2Cellular Component: nucleusMolecular Function: sequence-specific DNA bindingBiological Process: hypothalamus development; transcription, DNA-dependent; neuron fate commitment; spinal cord association neuron differentiation; adenohypophysis development; positive regulation of transcription from RNA polymerase II promoter
