The GSTT1 Polyclonal Antibody (CAB1287) is a valuable tool for researchers studying the Glutathione S-Transferase Theta 1 (GSTT1) enzyme, which plays a key role in the detoxification of xenobiotics and the maintenance of cellular redox balance. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.GSTT1 is a member of the glutathione S-transferase family, which plays a crucial role in protecting cells from oxidative stress and toxic compounds by catalyzing the conjugation of glutathione to a wide variety of substrates. Dysregulation of GSTT1 activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting the GSTT1 enzyme, researchers can gain insights into the mechanisms underlying cellular detoxification processes and oxidative stress response, as well as explore potential therapeutic strategies for combating diseases associated with GSTT1 dysfunction. The GSTT1 Polyclonal Antibody (CAB1287) offers a reliable tool for detecting and analyzing GSTT1 expression in a variety of cell types, making it a valuable asset for studies in toxicology, pharmacology, and disease pathology.
Product Name:
GSTT1 Rabbit Polyclonal Antibody
SKU:
CAB1287
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of GSTT1 (NP_000844.2).
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2952
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using GSTT1 Rabbit pAb (CAB1287) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
