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GSTT1/GSTT4 Antibody (PACO00892)

SKU:
PACO00892
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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GSTT1/GSTT4 Antibody (PACO00892)

The GSTT1/GSTT4 Antibody (PACO00892) is a high-quality polyclonal antibody designed for research involving GSTT1 and GSTT4 proteins, which are important members of the glutathione S-transferase family known for their role in detoxification processes in the body. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot analysis.GSTT1 and GSTT4 are involved in the metabolic activation and detoxification of various carcinogens and toxins in the body, making them important targets for studying the mechanisms of drug metabolism and chemical detoxification. The ability of this antibody to specifically bind to GSTT1 and GSTT4 proteins enables researchers to detect and analyze these proteins in different cell types, making it an ideal tool for studies in toxicology, pharmacology, and cancer research.

Understanding the functions and regulation of GSTT1 and GSTT4 proteins is crucial for developing new strategies for drug development, identifying biomarkers of disease, and exploring potential therapeutic targets for cancer and other diseases related to impaired detoxification processes. The use of the GSTT1/GSTT4 Antibody (PACO00892) in research can provide valuable insights into the role of these proteins in health and disease, contributing to advancements in personalized medicine and precision healthcare.

Antibody Name:GSTT1/GSTT4 Antibody
Antibody SKU:PACO00892
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the N-terminal region of human GSTT1/4.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GSTT1; Glutathione S-transferase theta-1; GST class-theta-1; Glutathione transferase T1-1; GSTT4; Glutathione S-transferase theta-4; GST class-theta-4
UniProt Protein Function:GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.
UniProt Protein Details:

Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.5.1.18

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function:glutathione peroxidase activity; glutathione transferase activity

Biological Process: glutathione metabolic process

NCBI Summary:The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:P30711
NCBI GenInfo Identifier:21264427
NCBI Gene ID:2952
NCBI Accession:P30711.4
UniProt Secondary Accession:P30711,O00226, Q5TZY2, Q6IC69, Q969K8, Q96IY3,
UniProt Related Accession:P30711
Molecular Weight:13,517 Da
NCBI Full Name:Glutathione S-transferase theta-1
NCBI Synonym Full Names:glutathione S-transferase theta 1
NCBI Official Symbol:GSTT1  
NCBI Protein Information:glutathione S-transferase theta-1
UniProt Protein Name:Glutathione S-transferase theta-1
UniProt Synonym Protein Names:GST class-theta-1; Glutathione transferase T1-1
Protein Family:Glutathione S-transferase
UniProt Gene Name:GSTT1  
UniProt Entry Name:GSTT1_HUMAN

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