Gstp1 Antibody (PACO27229)
- SKU:
- PACO27229
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Gstp1 Antibody (PACO27229)
The GSTP1 Polyclonal Antibody (PAC027229) is a valuable tool for researchers studying GSTP1, an important enzyme involved in detoxification and protection against oxidative stress. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the GSTP1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in toxicology, pharmacology, and cancer biology.
GSTP1 plays a critical role in protecting cells from damage caused by carcinogens and reactive oxygen species. Dysregulation of GSTP1 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, studying the expression and activity of GSTP1 is essential for understanding its role in disease development and progression, as well as for identifying potential therapeutic targets for intervention.
| Antibody Name: | Gstp1 Antibody (PACO27229) |
| Antibody SKU: | PACO27229 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Glutathione S-transferase P 1 protein (2-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Gstp1 antibody at 2µg/ml Lane 1: Mouse kidney tissue Lane 2: Jurkat whole cell lysate Lane 3: K562 whole cell lysate Lane 4: 293T whole cell lysate Lane 5: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24 kDa Observed band size: 24 kDa . |
| Background: | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration . |
| Synonyms: | Glutathione S-transferase P 1 (Gst P1) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piB) (Preadipocyte growth factor), Gstp1, Gstpib |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19157 |
| NCBI GenInfo Identifier: | 4504183 |
| NCBI Gene ID: | 2950 |
| NCBI Accession: | NP_000843.1 |
| UniProt Secondary Accession: | P19157,P19157 |
| UniProt Related Accession: | P19157,P09211 |
| Molecular Weight: | |
| NCBI Full Name: | glutathione S-transferase P |
| NCBI Synonym Full Names: | glutathione S-transferase pi 1 |
| NCBI Official Symbol: | GSTP1Â Â |
| NCBI Official Synonym Symbols: | PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22Â Â |
| NCBI Protein Information: | glutathione S-transferase P |
| UniProt Protein Name: | Glutathione S-transferase P |
| UniProt Synonym Protein Names: | GST class-pi; GSTP1-1 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTP1Â Â |
| UniProt Entry Name: | GSTP1_HUMAN |
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