The GSTO1 Polyclonal Antibody (CAB15354) is a valuable tool for research involving Glutathione S-Transferase Omega 1 (GSTO1), an enzyme involved in the detoxification of xenobiotics and reactive oxygen species. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to GSTO1, researchers can accurately detect and analyze this crucial enzyme in a variety of cell types, making it ideal for studies in oxidative stress, drug metabolism, and cancer research.GSTO1 is known for its role in cellular protection against oxidative damage and its involvement in the metabolism of certain chemotherapeutic agents.
Its significance in detoxification pathways and potential links to cancer development make it a promising target for investigation in various disease contexts. Understanding the function and regulation of GSTO1 can provide valuable insights into mechanisms of drug resistance and potential therapeutic options for combating oxidative stress-related diseases.Overall, the GSTO1 Polyclonal Antibody offers researchers a reliable tool for studying the role of GSTO1 in various physiological and pathological processes, highlighting its potential as a therapeutic target in conditions involving oxidative stress and drug metabolism.
Product Name:
GSTO1 Rabbit Polyclonal Antibody
SKU:
CAB15354
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human GSTO1 (NP_004823.1).
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9446
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSTO1 Rabbit pAb (CAB15354) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
