The GSTM3 Polyclonal Antibody (CAB7679) is a valuable tool for researchers studying the role of GSTM3, a member of the glutathione S-transferase family involved in detoxification processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the GSTM3 protein, this antibody enables accurate detection and analysis, allowing for precise investigation of GSTM3 expression in various cell types.GSTM3 plays a crucial role in protecting cells from oxidative damage and has been implicated in detoxifying harmful compounds, making it a key player in maintaining cellular health.
Research on GSTM3 is particularly relevant in the fields of toxicology, pharmacology, and cancer biology, as dysregulation of GSTM3 expression has been associated with drug resistance and increased susceptibility to environmental toxins.By utilizing the GSTM3 Polyclonal Antibody in their studies, researchers can gain valuable insights into the function and regulation of GSTM3 in normal cellular processes and disease states. This antibody serves as an essential tool for furthering our understanding of the role of GSTM3 in health and disease, ultimately paving the way for the development of targeted therapies and treatments.
Product Name:
GSTM3 Rabbit Polyclonal Antibody
SKU:
CAB7679
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-225 of human GSTM3 (NP_000840.2).
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSTM3 Rabbit pAb (CAB7679) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
