The GSTM3 Polyclonal Antibody (CAB3905) is a vital tool for researchers studying GSTM3, a member of the glutathione S-transferase family involved in detoxification processes within the body. This highly specific antibody, produced in rabbits, exhibits a strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GSTM3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in areas such as toxicology, pharmacology, and cancer research.
GSTM3 plays a crucial role in the detoxification of harmful substances by conjugating them with glutathione, thereby facilitating their removal from cells. Dysregulation of GSTM3 has been implicated in various health conditions, including cancer, neurodegenerative diseases, and drug resistance. By studying the function and expression of GSTM3 using this antibody, researchers can gain valuable insights into the mechanisms of detoxification and potentially identify new therapeutic strategies to target diseases related to GSTM3 dysfunction.
Product Name:
GSTM3 Rabbit Polyclonal Antibody
SKU:
CAB3905
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-225 of human GSTM3 (NP_000840.2).
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSTM3 Rabbit pAb (CAB3905) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
