The GSTM1 Polyclonal Antibody (CAB17492) is a valuable tool for researchers studying the glutathione S-transferase mu 1 (GSTM1) protein, which plays a crucial role in detoxifying electrophilic compounds and protecting cells from oxidative damage. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications.The GSTM1 protein belongs to the GST superfamily, which is involved in the metabolism of various endogenous and exogenous substances, including carcinogens and drugs.
Deficiencies in GSTM1 have been associated with an increased risk of cancer development and susceptibility to environmental toxins.By using the GSTM1 Polyclonal Antibody, researchers can detect and analyze the expression of GSTM1 in different cell types and tissues, providing valuable insights into its function in normal physiological processes and disease states. This antibody is an essential tool for studies investigating the role of GSTM1 in cancer biology, drug metabolism, and toxicology.
Product Name:
GSTM1 Rabbit Polyclonal Antibody
SKU:
CAB17492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human GSTM1 (NP_666533.1).
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
2944
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using (CAB17492) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
