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GSTA4 Monoclonal Antibody

SKU:
CAB23555
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

GSTA4 Monoclonal Antibody (CAB23555)

The GSTA4 Monoclonal Antibody is a valuable tool for researchers studying GSTA4, a member of the glutathione S-transferase family involved in detoxification processes. This monoclonal antibody, generated in mouse, exhibits high specificity and sensitivity towards human samples, making it ideal for various research applications, including Western blot and immunohistochemistry.GSTA4 plays a critical role in cellular defense against oxidative stress and toxic compounds by facilitating the conjugation of glutathione to xenobiotics. Dysregulation of GSTA4 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic intervention.

By using the GSTA4 Monoclonal Antibody, researchers can gain insights into the expression and activity of GSTA4 in different tissues and cell types, advancing our understanding of its role in health and disease. This antibody is a valuable tool for studying the mechanisms underlying GSTA4 function and for potentially developing novel therapeutic strategies targeting GSTA4-related pathways.

Product Name:GSTA4 Monoclonal Antibody
Product Code:CAB23555
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC3110
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:293T, Hep G2
Cellular Location:Cytoplasm

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.

Immunogen:Recombinant protein of human GSTA4.
Sequence:Email for sequence
Synonyms:GTA4, GSTA4-4
Calculated MW:26kDa
Observed MW:26kDa

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