GSTA3 Rabbit Polyclonal Antibody (CAB17491)
- SKU:
- CAB17491
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GSTA3 Rabbit Polyclonal Antibody |
SKU: | CAB17491 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA3 (NP_000838.3). |
Sequence: | MAGK PKLH YFNG RGRM EPIR WLLA AAGV EFEE KFIG SAED LGKL RNDG SLMF QQVP MVEI DGMK LVQT RAIL NYIA SKYN LYGK DIKE RALI DMYT EGMA DLNE MILL LPLC RPEE KDAK IALI KEKT KSRY FPAF EKVL QSHG QDYL VGNK LSRA DISL VELL YYVE ELDS SLIS NFPL LKAL KTRI SNLP TVKK FLQP GSPR KPPA DAKA LEEA RKIF RF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | GTA3; GSTA3-3; GSTA3 |
Positive Sample: | PC-3,293T,Mouse lung,Mouse liver,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular exosome |
Calculated MW: | 25kDa |
Observed MW: | 25kDa |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 2940 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |