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GSTA2 Rabbit Polyclonal Antibody (CAB7678)

SKU:
CAB7678
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-GSTA2 Antibody CAB7678
  • Cell Biology Antibodies 11 Anti-GSTA2 Antibody CAB7678
€139 - €419
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Description

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GSTA2 Rabbit Polyclonal Antibody (CAB7678)

The GSTA2 Polyclonal Antibody (CAB7678) is a valuable tool for researchers studying GSTA2, an enzyme involved in detoxification processes and drug metabolism. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the GSTA2 protein, this antibody allows for the detection and analysis of GSTA2 expression in various cell types, making it ideal for studies in toxicology, pharmacology, and cancer research.

GSTA2 plays a crucial role in protecting cells from damage caused by reactive oxygen species and xenobiotics, making it a potential target for therapies aimed at enhancing detoxification pathways or sensitizing cancer cells to chemotherapy. Understanding the function and regulation of GSTA2 is essential for developing strategies to modulate its activity in the context of drug metabolism and disease.

Product Name:GSTA2 Rabbit Polyclonal Antibody
SKU:CAB7678
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA2 (NP_000837.3).
Sequence:MAEK PKLH YSNI RGRM ESIR WLLA AAGV EFEE KFIK SAED LDKL RNDG YLMF QQVP MVEI DGMK LVQT RAIL NYIA SKYN LYGK DIKE KALI DMYI EGIA DLGE MILL LPFS QPEE QDAK LALI QEKT KNRY FPAF EKVL KSHG QDYL VGNK LSRA DIHL VELL YYVE ELDS SLIS SFPL LKAL KTRI SNLP TVKK FLQP GSPR KPPM DEKS LEES RKIF RF
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:GST2; GTA2; GTH2; GSTA2-2; GSTA2
Positive Sample:Mouse liver,Mouse testis,Rat liver,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:26kDa
Observed MW:25kDa

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Purification Method:Affinity purification
Gene ID:2939
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using GSTA2 antibody (CAB7678) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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