The GSTA1 Polyclonal Antibody (CAB18266) is a versatile tool for researchers studying the GSTA1 enzyme, which plays a key role in detoxification processes within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the GSTA1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in the fields of toxicology, drug metabolism, and cancer research.GSTA1 is a member of the glutathione S-transferase family, essential for the conjugation of toxic substances with glutathione for elimination from the body.
Dysregulation of GSTA1 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a valuable target for therapeutic development. By studying the function and regulation of GSTA1 with this antibody, researchers can gain valuable insights into the mechanisms of detoxification and potentially discover new strategies for treating GSTA1-related conditions.
Product Name:
GSTA1 Rabbit Polyclonal Antibody
SKU:
CAB18266
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1).
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2938
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSTA1 Rabbit pAb (CAB18266) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
