The GSTA1 Polyclonal Antibody (CAB1628) is a valuable tool for researchers studying the GSTA1 enzyme, which plays a key role in detoxifying xenobiotics and carcinogens. This antibody, raised in rabbits, has high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By binding to the GSTA1 protein, researchers can analyze and detect its expression in various cell types, aiding in studies related to drug metabolism, oxidative stress, and cancer research.GSTA1 is a critical enzyme belonging to the glutathione S-transferase family, known for its role in protecting cells from oxidative damage and maintaining cellular homeostasis.
Its involvement in detoxification pathways makes it a potential target for therapies targeting drug resistance in cancer cells or for developing strategies to enhance drug efficacy. By understanding the function and expression of GSTA1, researchers can gain insights into its potential as a therapeutic target in various disease contexts.
Product Name:
GSTA1 Rabbit Polyclonal Antibody
SKU:
CAB1628
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1).
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2938
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using GSTA1 Rabbit pAb (CAB1628) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
