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GSS Monoclonal Antibody [PAT12F2AT] (CPAB0241)

SKU:
CPAB0241
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT12F2AT
Applications:
WB
ELISA
€149
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Description

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GSS Monoclonal Antibody [PAT12F2AT] (CPAB0241)

The GSS Polyclonal Antibody (CPAB0241) is a valuable tool for researchers studying GSS, a key enzyme involved in the production and metabolism of glutathione, an important antioxidant in the body. This antibody, produced in rabbits, is highly specific to GSS in human samples and is validated for use in Western blot applications. By targeting the GSS protein, this antibody enables the detection and analysis of GSS levels in various cell types, making it essential for studies in oxidative stress, metabolism, and diseases related to glutathione dysregulation.

GSS, also known as glutathione synthetase, plays a crucial role in maintaining cellular redox balance and protecting cells from oxidative damage. Dysregulation of GSS activity has been implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic diseases. By understanding the function and regulation of GSS, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop novel therapeutic strategies targeting GSS activity.

Product Name:GSS Antibody
Product Sku:CPAB0241
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GSS mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GSS amino acids 1-474 purified from Ecoli.
Clone:PAT12F2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:GSS antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Glutathione synthetase (GSS) is the second enzyme in the glutathione biosynthesis pathway. GSS catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Defects in the GSS are the cause of glutathione synthetase deficiency aka GSS deficiency or 5-oxoprolinuria or pyroglutamic aciduria, which is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Synonyms:Glutathione synthetase, GSH synthetase, GSH-S, Glutathione synthase, GSHS, MGC14098, GSS.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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