The GSR Polyclonal Antibody (CAB12070) offered by AssayGenie is a valuable tool for researchers studying Glutathione Reductase (GSR) in various cellular processes. This antibody is produced in rabbits and shows high reactivity with human samples, making it suitable for use in Western blot applications.GSR is an important enzyme involved in the maintenance of cellular redox balance by catalyzing the reduction of oxidized glutathione (GSSG) to its reduced form (GSH). This process is crucial for protecting cells from oxidative damage and maintaining proper cellular function. The GSR Polyclonal Antibody binds specifically to GSR, allowing for its detection and analysis in different cell types.
Research on GSR is relevant to a wide range of fields, including oxidative stress, aging, neurodegenerative diseases, and cancer. By understanding the role of GSR in these processes, researchers may uncover novel therapeutic targets for treating conditions associated with oxidative stress and redox imbalance.Overall, the GSR Polyclonal Antibody provided by AssayGenie is a valuable tool for investigating the function and regulation of GSR in various biological contexts, offering potential insights into the development of targeted therapies for diseases related to oxidative stress.
Product Name:
GSR Rabbit Polyclonal Antibody
SKU:
CAB12070
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 273-522 of human GSR (NP_000628.2).
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Purification Method:
Affinity purification
Gene ID:
2936
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSR Rabbit pAb (CAB12070) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
