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GSR Monoclonal Antibody [PAT11D10AT] (CPAB0192)

SKU:
CPAB0192
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT11D10AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

GSR Monoclonal Antibody [PAT11D10AT] (CPAB0192)

The GSR Polyclonal Antibody (CPAB0192) from Assay Genie is a valuable tool for researchers studying the glutathione reductase (GSR) protein, which plays a crucial role in antioxidant defense and maintaining cellular redox balance. This antibody is produced in rabbits and has been validated for use in Western blot applications, enabling the detection and analysis of GSR in various cell types.GSR is an essential enzyme that catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH), a key antioxidant in cells. Dysregulation of GSR has been implicated in oxidative stress-related diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases.

The GSR Polyclonal Antibody allows researchers to investigate the expression levels and localization of GSR in different experimental settings, providing valuable insights into its role in redox homeostasis and disease pathogenesis.By using the GSR Polyclonal Antibody from Assay Genie, researchers can deepen their understanding of GSR function and signaling pathways, paving the way for the development of targeted therapies for oxidative stress-related conditions.

Product Name:GSR Antibody
Product Sku:CPAB0192
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GSR mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GSR amino acids 43-522 purified from Ecoli.
Clone:PAT11D10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:GSR antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Glutathione reductase (GSR) belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. The GSR enzyme is a homodimeric flavoprotein and has a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ->2GSH + NADP+. In the majority of eukaryotic cells, GSR upholds the ratio of [GSH] / [GSSG], and partakes in quite a few critical functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Synonyms:Glutathione reductase mitochondrial, GR, GRase, GSR, GLUR, GRD1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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