The GSK3B Polyclonal Antibody (CAB6164) is a valuable tool for researchers studying GSK3B, a key protein involved in various cellular processes such as cell growth, proliferation, and differentiation. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications.GSK3B, also known as glycogen synthase kinase 3 beta, is a critical regulator of numerous signaling pathways and has been implicated in the development of various diseases including cancer, diabetes, and neurodegenerative disorders. By targeting GSK3B, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.
With its ability to specifically bind to GSK3B protein, the CAB6164 antibody enables precise detection and analysis of GSK3B in different cell types, making it a versatile tool for studies in molecular biology, cell signaling, and drug discovery. By utilizing this antibody, researchers can further elucidate the functions of GSK3B and its role in disease pathology, paving the way for the development of innovative treatment strategies.
Product Name:
[KO Validated] GSK3β Rabbit Polyclonal Antibody
SKU:
CAB6164
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 320-420 of human GSK3β (NP_001139628.1).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsIF/ICC,1:50 - 1:200
Synonyms:
GSK3B; gsk-3β; GSK3β
Positive Sample:
LO2,HeLa,22Rv1,U-251MG
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm, Nucleus.
Calculated MW:
47kDa
Observed MW:
46kDa
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
Purification Method:
Affinity purification
Gene ID:
2932
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GSK3β Rabbit pAb (CAB6164) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
