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GSK3β Polyclonal Antibody

SKU:
CAB21444
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

GSK3β Polyclonal Antibody (CAB21444)

The GSK3 Polyclonal Antibody is a valuable tool for researchers studying glycogen synthase kinase 3 (GSK3), a key enzyme involved in various signaling pathways within cells. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blotting applications. By binding specifically to GSK3 protein, this antibody allows for the detection and analysis of GSK3 levels in different cell types, making it an essential tool for research in cell biology, neuroscience, and cancer research.GSK3 is a multifunctional kinase that plays a crucial role in various cellular processes, including cell growth, proliferation, and differentiation. Dysregulation of GSK3 activity has been linked to the development of several human diseases, including cancer, neurodegenerative disorders, and diabetes.

By understanding the function and regulation of GSK3, researchers can gain valuable insights into the underlying mechanisms of these diseases and identify potential therapeutic targets for drug development.Overall, the GSK3 Polyclonal Antibody is a reliable tool for researchers investigating the role of GSK3 in health and disease. Its high specificity and sensitivity make it a valuable asset for studying the intricate signaling pathways controlled by GSK3 and its implications in various physiological and pathological conditions.

Product Name:GSK3β Polyclonal Antibody
Product Code:CAB21444
Reactivity:Human, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T, C6
Cellular Location:Cell membrane, Cytoplasm, Nucleus

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of GSK3β (NP_001139628.1).
Sequence:LPNGR DTPAL FNFTT QELSS NPPLA TILIP PHARI QAAAS TPTNA TAASD ANTGD RGQTN NAASA SASNS T
Synonyms:GSK3B, glycogen synthase kinase-3 beta
Calculated MW:47kDa
Observed MW:47kDa

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