Anti-GSDMD Antibody (CAB18281)
- SKU:
- CAB18281
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Anti-GSDMD Antibody (CAB18281)
The GSDMD Polyclonal Antibody (CAB18281) is a valuable tool for researchers studying gasdermin D (GSDMD), a protein involved in pyroptosis, a highly inflammatory form of programmed cell death. This rabbit-derived antibody is highly specific and reactive with human samples, making it an excellent choice for studies involving GSDMD in Western blot applications.Gasdermin D has emerged as a key player in the inflammatory response, particularly in the context of infectious diseases and immune dysregulation. By targeting GSDMD, researchers can gain insights into the mechanisms underlying pyroptosis and its role in various pathological conditions, including sepsis, inflammatory bowel disease, and cancer.
Understanding the function of GSDMD is pivotal for developing targeted therapies that modulate inflammatory responses and improve clinical outcomes.Overall, the GSDMD Polyclonal Antibody (CAB18281) offers a reliable and effective tool for investigating the role of gasdermin D in inflammation and disease pathogenesis, providing valuable insights for both basic research and therapeutic development.
| Antibody Name: | Anti-GSDMD Antibody |
| Antibody SKU: | CAB18281 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human GSDMD. |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, THP-1, Jurkat, Rat spleen |
| Immunogen: | Recombinant protein of human GSDMD. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79792 |
| Uniprot: | P57764 |
| Cellular Location: | |
| Calculated MW: | 53kDa |
| Observed MW: | 53KDa/23KDa |
 | Western blot - GSDMD Rabbit pAb (CAB18281) |
| Synonyms: | DF5L, DFNA5L, FKSG10, GSDMDC1, GSDMD |
| Background: | Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | FKSG10: Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009] |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; NLRP3 inflammasome complex; nucleoplasm; plasma membrane; tertiary granule lumen Molecular Function:cardiolipin binding; phosphatidic acid binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylserine binding; protein binding Biological Process: cellular response to extracellular stimulus; cytolysis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; inflammatory response; innate immune response; neutrophil degranulation; pore complex assembly; positive regulation of interleukin-1 beta secretion; protein homooligomerization; pyroptosis |
| NCBI Summary: | Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P57764 |
| NCBI GenInfo Identifier: | 261878494 |
| NCBI Gene ID: | 79792 |
| NCBI Accession: | NP_001159709.1 |
| UniProt Secondary Accession: | P57764,Q96Q98, A8K702, D3DWJ9, |
| UniProt Related Accession: | P57764 |
| Molecular Weight: | 52,801 Da |
| NCBI Full Name: | gasdermin-D |
| NCBI Synonym Full Names: | gasdermin D |
| NCBI Official Symbol: | GSDMDÂ Â |
| NCBI Official Synonym Symbols: | DF5L; DFNA5L; FKSG10; GSDMDC1Â Â |
| NCBI Protein Information: | gasdermin-D |
| UniProt Protein Name: | Gasdermin-D |
| UniProt Synonym Protein Names: | Gasdermin domain-containing protein 1 |
| Protein Family: | Gasdermin |
| UniProt Gene Name: | GSDMDÂ Â |
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