GRPR Rabbit Polyclonal Antibody (CAB2940)
- SKU:
- CAB2940
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | GRPR Rabbit Polyclonal Antibody |
SKU: | CAB2940 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). |
Sequence: | KNLI QSAY NLPV EGNI HVKK QIES RKRL AKTV LVFV GLFA FCWL PNHV IYLY RSYH YSEV DTSM LHFV TSIC ARLL AFTN SCVN PFAL YLLS KSFR KQFN TQLL CCQP GLII RSHS TGRS TTCM TSLK STNP SVAT FSLI NGNI CHER YV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BB2; BB2R; BRS2; GRPR |
Positive Sample: | U-87MG,SGC-7901,A-549,MCF7,Mouse brain,Mouse pancreas,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 43kDa |
Observed MW: | 43kDa |
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Purification Method: | Affinity purification |
Gene ID: | 2925 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |