The GRPEL1 Polyclonal Antibody (CAB4999) is specifically designed for research involving GRPEL1, a protein essential for mitochondrial function and cellular energy production. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GRPEL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in mitochondrial biology and oxidative phosphorylation research.GRPEL1, also known as mitochondrial chaperone GRPE-like 1, plays a crucial role in maintaining mitochondrial protein homeostasis and assisting in the folding of newly synthesized proteins within the organelle.
Dysregulation of GRPEL1 has been associated with mitochondrial dysfunction and energy metabolism disorders, making it a promising target for investigation in diseases such as neurodegenerative disorders, metabolic syndromes, and aging-related conditions.By understanding the function and regulation of GRPEL1, researchers can gain insights into the mechanisms underlying mitochondrial health and energy production, potentially leading to the development of therapeutic strategies targeting mitochondrial dysfunction in various disease contexts. The GRPEL1 Polyclonal Antibody provides a reliable tool for investigating the role of GRPEL1 in cellular physiology and disease pathogenesis.
Product Name:
GRPEL1 Rabbit Polyclonal Antibody
SKU:
CAB4999
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GRPEL1 (NP_079472.1).
Enables identical protein binding activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial matrix and nucleoplasm.
Purification Method:
Affinity purification
Gene ID:
80273
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using GRPEL1 Rabbit pAb (CAB4999) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
