GRM4 Rabbit Polyclonal Antibody (CAB7284)
- SKU:
- CAB7284
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GRM4 Rabbit Polyclonal Antibody |
SKU: | CAB7284 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1). |
Sequence: | KPKG HPHM NSIR IDGD ITLG GLFP VHGR GSEG KPCG ELKK EKGI HRLE AMLF ALDR INND PDLL PNIT LGAR ILDT CSRD THAL EQSL TFVQ ALIE KDGT EVRC GSGG PPII TKPE RVVG VIGA SGSS VSIM VANI LRLF KIPQ ISYA STAP DLSD NSRY DFFS RVVP SDTY QAQA MVDI VRAL KWNY VSTV ASEG SYGE SGVE AFIQ KSRE DGGV CIAQ SVKI PREP KAGE FDKI IRRL LETS NARA VIIF ANED DI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | mGlu4; GPRC1D; MGLUR4; GRM4 |
Positive Sample: | Mouse spinal cord,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 102kDa |
Observed MW: | 115kDa |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2914 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |