GRM3 Rabbit Polyclonal Antibody (CAB2538)
- SKU:
- CAB2538
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | GRM3 Rabbit Polyclonal Antibody |
SKU: | CAB2538 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-170 of human GRM3 (NP_000831.2). |
Sequence: | LGDH NFLR REIK IEGD LVLG GLFP INEK GTGT EECG RINE DRGI QRLE AMLF AIDE INKD DYLL PGVK LGVH ILDT CSRD TYAL EQSL EFVR ASLT KVDE AEYM CPDG SYAI QENI PLLI AGVI GGSY SSVS IQVA NLLR LFQI PQIS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GLUR3; mGlu3; GPRC1C; MGLUR3; GRM3 |
Positive Sample: | Raji,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 99kDa |
Observed MW: | 112kDa |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Purification Method: | Affinity purification |
Gene ID: | 2913 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |