GRM1 Rabbit Polyclonal Antibody (CAB11462)
- SKU:
- CAB11462
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GRM1 Rabbit Polyclonal Antibody |
SKU: | CAB11462 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140 of human GRM1 (NP_001264993.1). |
Sequence: | NETA CNQT AVIK PLTK SYQG SGKS LTFS DTST KTLY NVEE EEDA QPIR FSPP GSPS MVVH RRVP SAAT TPPL PSHL TAEE TPLF LAEP ALPK GLPP PLQQ QQQP PPQQ KSLM DQLQ GVVS NFST AIPD FHAV LAGP GGPG NGLR SLYP PPPP PQHL QMLP LQLS TFGE ELVS PPAD DDDD SERF KLLQ EYVY EHER EGNT EEDE LEEE EEDL QAAS KLTP D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; GRM1 |
Positive Sample: | HL-60,MCF7,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 132kDa |
Observed MW: | 132kDa |
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 2911 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |