The GRM1 Polyclonal Antibody (CAB11462) is a valuable tool for researchers studying the metabotropic glutamate receptor 1 (GRM1) protein. This antibody, generated in rabbits, is highly specific and reactive to human samples, making it ideal for Western blot applications. By binding to the GRM1 protein, researchers can effectively detect and analyze its expression in various cell types.The GRM1 protein is a key player in neurotransmission and has been implicated in a variety of neurological disorders, including epilepsy and schizophrenia. Additionally, aberrant expression of GRM1 has been linked to certain types of cancer, making it an attractive target for cancer research.
Understanding the role of GRM1 in these diseases can provide insights into potential therapeutic strategies targeting this protein.Overall, the GRM1 Polyclonal Antibody is a valuable tool for researchers looking to unravel the complex functions of the GRM1 protein in health and disease. Its high reactivity and specificity make it a reliable choice for studies in neuroscience, cancer biology, and beyond.
Product Name:
GRM1 Rabbit Polyclonal Antibody
SKU:
CAB11462
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140 of human GRM1 (NP_001264993.1).
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
2911
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GRM1 antibody (CAB11462) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
