The GRM1 Polyclonal Antibody (CAB11094) is a valuable tool for researchers studying the metabotropic glutamate receptor 1 (GRM1), a key player in neurological function and disease. This antibody, developed through rabbit immunization, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the GRM1 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in neuroscience and neurodegenerative disorders.GRM1, a member of the G protein-coupled receptor family, is known for its role in modulating synaptic transmission and neuronal excitability.
Dysregulation of GRM1 has been linked to conditions such as schizophrenia, epilepsy, and Parkinson's disease, highlighting its importance in brain function. By understanding the function and regulation of GRM1, researchers can pave the way for new therapeutic strategies targeting neurological disorders.Overall, the GRM1 Polyclonal Antibody (CAB11094) offers researchers a reliable tool for investigating the role of GRM1 in neurological processes and diseases, ultimately advancing our understanding of the brain and potentially leading to the development of novel treatment approaches.
Product Name:
GRM1 Rabbit Polyclonal Antibody
SKU:
CAB11094
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 921-1010 of human GRM1 (NP_001264993.1).
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
2911
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of rat liver, using GRM1 antibody (CAB11094) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
