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GRK7 Antibody (PACO00888)

SKU:
PACO00888
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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GRK7 Antibody (PACO00888)

The GRK7 Monoclonal Antibody (PACO00888) is a valuable tool for researchers studying G protein-coupled receptor kinase 7 (GRK7), a kinase protein involved in the regulation of visual phototransduction. This antibody, developed using advanced monoclonal technology, is highly specific to GRK7 in various species, including human, mouse, and rat, making it versatile for a wide range of experimental settings.GRK7 plays a crucial role in the phototransduction cascade in the retina, specifically in the adaptation of photoreceptor cells to different light conditions. Dysregulation of GRK7 has been implicated in visual disorders such as retinitis pigmentosa and night blindness, making it a promising target for therapeutic interventions.

This monoclonal antibody is ideal for detecting and quantifying GRK7 levels in cell lysates or tissue samples, offering researchers a powerful tool for investigating the role of GRK7 in visual signal transduction pathways. Whether studying normal vision processes or exploring potential treatments for retinal diseases, the GRK7 Monoclonal Antibody is a reliable resource for advancing research in ophthalmology and visual neuroscience.

Antibody Name:GRK7 Antibody
Antibody SKU:PACO00888
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human GRK 7.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GRK7; GPRK7; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
UniProt Protein Function:GRK7: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
UniProt Protein Details:

Protein type:EC 2.7.11.14; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily

Chromosomal Location of Human Ortholog: 3q24

Molecular Function:rhodopsin kinase activity

Biological Process: protein amino acid autophosphorylation; regulation of rhodopsin mediated signaling

NCBI Summary:This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WTQ7
NCBI GenInfo Identifier:21263659
NCBI Gene ID:131890
NCBI Accession:Q8WTQ7.1
UniProt Related Accession:Q8WTQ7
Molecular Weight:62,212 Da
NCBI Full Name:Rhodopsin kinase
NCBI Synonym Full Names:G protein-coupled receptor kinase 7
NCBI Official Symbol:GRK7  
NCBI Official Synonym Symbols:GPRK7  
NCBI Protein Information:rhodopsin kinase
UniProt Protein Name:Rhodopsin kinase
UniProt Synonym Protein Names:G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
Protein Family:Rhodopsin kinase
UniProt Gene Name:GRK7  
UniProt Entry Name:GRK7_HUMAN

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