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GRK7 Antibody, FITC conjugated (PACO64117)

SKU:
PACO64117
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
FITC
€339
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Description

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GRK7 Antibody, FITC conjugated (PACO64117)

The GRK7 Antibody FITC Conjugated (PAC064117) is a valuable tool for researchers studying G protein-coupled receptor kinase 7 (GRK7), a key regulator of phototransduction in the retina. This antibody, conjugated with fluorescein isothiocyanate (FITC), allows for easy visualization and detection of GRK7 in various biological samples.GRK7 is crucial for the proper functioning of photoreceptor cells in the retina, playing a vital role in the visual signaling cascade. Dysregulation of GRK7 has been linked to disorders like retinitis pigmentosa and other retinal degenerative diseases. By using the GRK7 Antibody FITC Conjugated, researchers can study the expression and localization of GRK7 in different cell types and tissues, providing important insights into retinal biology and potential therapeutic targets for vision-related disorders.

With its high specificity and sensitivity, the GRK7 Antibody FITC Conjugated is a valuable tool for immunofluorescence and other imaging techniques, facilitating detailed analysis of GRK7 distribution and function. This antibody is a must-have for scientists conducting research in the fields of vision science, ophthalmology, and neurobiology.

Antibody Name:GRK7 Antibody?FITC conjugated (PACO64117)
Antibody SKU:PACO64117
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Rhodopsin kinase protein (342-550AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Antigen Affinity purified & Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:FITC
Background:Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Synonyms:Rhodopsin kinase (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7), GRK7, GPRK7
UniProt Protein Function:GRK7: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
UniProt Protein Details:

Protein type:EC 2.7.11.14; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily

Chromosomal Location of Human Ortholog: 3q24

Molecular Function:rhodopsin kinase activity

Biological Process: protein amino acid autophosphorylation; regulation of rhodopsin mediated signaling

NCBI Summary:This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WTQ7
NCBI GenInfo Identifier:21263659
NCBI Gene ID:131890
NCBI Accession:Q8WTQ7.1
UniProt Related Accession:Q8WTQ7
Molecular Weight:62,212 Da
NCBI Full Name:Rhodopsin kinase
NCBI Synonym Full Names:G protein-coupled receptor kinase 7
NCBI Official Symbol:GRK7  
NCBI Official Synonym Symbols:GPRK7  
NCBI Protein Information:rhodopsin kinase
UniProt Protein Name:Rhodopsin kinase
UniProt Synonym Protein Names:G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
Protein Family:Rhodopsin kinase
UniProt Gene Name:GRK7  
UniProt Entry Name:GRK7_HUMAN

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