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GRK7 Antibody, Biotin conjugated (PACO64118)

SKU:
PACO64118
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Biotin
$407
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Description

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GRK7 Antibody, Biotin conjugated (PACO64118)

The GRK7 Antibody (Biotin Conjugated) is a valuable tool for researchers studying G protein-coupled receptor kinase 7 (GRK7) and its role in photoreceptor cells. This antibody, conjugated to biotin for detection convenience, has been raised in rabbits and is highly specific for human samples. It has been validated for use in various applications, including Western blot and immunohistochemistry, enabling the detection and analysis of GRK7 in different cell types and tissues.

GRK7 is a key player in the visual system, specifically in the process of phototransduction in the retina. Its dysregulation has been linked to retinal diseases such as retinitis pigmentosa, making it a promising target for therapeutic interventions. By using the GRK7 Antibody, researchers can further explore the mechanisms of GRK7 function and its implications in vision disorders, paving the way for potential treatments and therapies in the future.

Antibody Name:GRK7 Antibody?Biotin conjugated (PACO64118)
Antibody SKU:PACO64118
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Rhodopsin kinase protein (342-550AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Antigen Affinity purified & Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Biotin
Background:Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
Synonyms:Rhodopsin kinase (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7), GRK7, GPRK7
UniProt Protein Function:GRK7: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
UniProt Protein Details:

Protein type:EC 2.7.11.14; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.16; AGC group; GRK family; GRK subfamily

Chromosomal Location of Human Ortholog: 3q24

Molecular Function:rhodopsin kinase activity

Biological Process: protein amino acid autophosphorylation; regulation of rhodopsin mediated signaling

NCBI Summary:This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WTQ7
NCBI GenInfo Identifier:21263659
NCBI Gene ID:131890
NCBI Accession:Q8WTQ7.1
UniProt Related Accession:Q8WTQ7
Molecular Weight:62,212 Da
NCBI Full Name:Rhodopsin kinase
NCBI Synonym Full Names:G protein-coupled receptor kinase 7
NCBI Official Symbol:GRK7  
NCBI Official Synonym Symbols:GPRK7  
NCBI Protein Information:rhodopsin kinase
UniProt Protein Name:Rhodopsin kinase
UniProt Synonym Protein Names:G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
Protein Family:Rhodopsin kinase
UniProt Gene Name:GRK7  
UniProt Entry Name:GRK7_HUMAN

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