The GRK6 Polyclonal Antibody (CAB6379) is a valuable tool for researchers studying G protein-coupled receptor kinase 6 (GRK6), a key player in the regulation of G protein-coupled receptors (GPCRs) signaling pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.GRK6 is known to play a crucial role in modulating GPCR signaling by phosphorylating and desensitizing these receptors, thereby regulating downstream signaling events.
Dysregulation of GRK6 activity has been implicated in a variety of diseases, including cardiovascular disorders, neurological disorders, and cancer.By targeting GRK6 with this antibody, researchers can better understand the mechanisms underlying GPCR regulation and explore potential therapeutic strategies for diseases associated with GPCR signaling imbalance. This antibody is an essential tool for studies in pharmacology, cell signaling, and drug development.
Product Name:
GRK6 Rabbit Polyclonal Antibody
SKU:
CAB6379
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
2870
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GRK6 antibody (CAB6379) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
