The GRK5 Polyclonal Antibody (CAB3899) is a valuable tool for researchers studying G protein-coupled receptor kinase 5 (GRK5), a key regulator of G protein-coupled receptor signaling pathways. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications.GRK5 plays a critical role in the desensitization and internalization of G protein-coupled receptors, making it a crucial mediator of cellular responses to hormones, neurotransmitters, and other signaling molecules.
Dysregulation of GRK5 has been implicated in various diseases, including heart failure, hypertension, and diabetes, making it an important target for therapeutics development.By specifically binding to the GRK5 protein, this antibody enables researchers to detect and analyze GRK5 expression in various cell types, providing insights into its function and potential implications in disease. Its versatility and reliability make it an ideal tool for studies in pharmacology, cell signaling, and drug discovery.
Product Name:
GRK5 Rabbit Polyclonal Antibody
SKU:
CAB3899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 371-590 of human GRK5 (NP_005299.1).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
Purification Method:
Affinity purification
Gene ID:
2869
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRK5 Rabbit pAb (CAB3899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
