The GRIPAP1 Polyclonal Antibody (PAC021462) is a valuable tool for researchers studying the GRIP-associated protein 1, which plays a role in the regulation of AMPA receptor trafficking and synaptic plasticity. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GRIPAP1 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.
GRIPAP1 is known to interact with GRIP1, a protein that mediates the trafficking of AMPA receptors, crucial for synaptic transmission and plasticity. Understanding the role of GRIPAP1 in this process is essential for uncovering its potential involvement in neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy. Research focused on GRIPAP1 can provide insights into the molecular mechanisms underlying synaptic dysfunction and help identify new targets for therapeutic intervention in these conditions.
Antibody Name:
Gripap1 Antibody (PACO21462)
Antibody SKU:
PACO21462
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa. 814-818(Q-E-I-V-R ) derived from Rat GRASP.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K. and Jingami, H. 2007. Crystal structures of autoinhibitory PDZ domain of Tamalin EMBO J.26: 2192-2205.
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from rat brain and mouse brain tissue using GRASP Antibody.
Synonyms:
Gripap; Grasp; GRIP1-associated protein
UniProt Protein Function:
Subunit structure: Interacts with GRIP1, GRIP2 and AMPA receptors. Ref.1Subcellular location: Early endosome By similarity. Tissue specificity: Expressed in the central nervous system; especially in neurons. Ref.1Post-translational modification: Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Ref.1
UniProt Protein Details:
NCBI Summary:
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
