GRIN2B Rabbit Polyclonal Antibody (CAB3056)
- SKU:
- CAB3056
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | GRIN2B Rabbit Polyclonal Antibody |
SKU: | CAB3056 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1185-1484 of human GRIN2B (NP_000825.2). |
Sequence: | DKHG VVSG VPAP WEKN LTNV EWED RSGG NFCR SCPS KLHN YSTT VTGQ NSGR QACI RCEA CKKA GNLY DISE DNSL QELD QPAA PVAV TSNA STTK YPQS PTNS KAQK KNRN KLRR QHSY DTFV DLQK EEAA LAPR SVSL KDKG RFMD GSPY AHMF EMSA GEST FANN KSSV PTAG HHHH NNPG GGYM LSKS LYPD RVTQ NPFI PTFG DDQC LLHG SKSY FFRQ PTVA GASK ARPD FRAL VTNK PVVS ALHG AVPA RFQK DICI GNQS NPCV PNNK NPRA FNGS SNGH VYEK LSSI ESDV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B; GRIN2B |
Positive Sample: | C6,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse. |
Calculated MW: | 166kDa |
Observed MW: | 166kDa |
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
Purification Method: | Affinity purification |
Gene ID: | 2904 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |