The GRIN2B Polyclonal Antibody (CAB3056) is a valuable tool for researchers studying the GRIN2B protein, a subunit of the N-methyl-D-aspartate (NMDA) receptor involved in synaptic plasticity and memory formation. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.GRIN2B is essential for the functioning of the NMDA receptor, which is involved in processes such as learning, memory, and neuronal development. Dysregulation of the NMDA receptor has been implicated in various neurological disorders, including schizophrenia, epilepsy, and Alzheimer's disease.
The GRIN2B Polyclonal Antibody allows for the detection and analysis of GRIN2B in various cell types, providing researchers with valuable insights into the role of this protein in health and disease.By studying the expression and activity of GRIN2B, researchers can gain a better understanding of how the NMDA receptor functions and its implications for neurological disorders. This antibody is a valuable tool for studies in neuroscience, pharmacology, and drug discovery, offering insights that may lead to the development of novel therapies for these conditions.
Product Name:
GRIN2B Rabbit Polyclonal Antibody
SKU:
CAB3056
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1185-1484 of human GRIN2B (NP_000825.2).
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
Purification Method:
Affinity purification
Gene ID:
2904
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRIN2B Rabbit pAb (CAB3056) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
