The GRIN2B Antibody (PAC021517) is a valuable research tool for scientists studying the GRIN2B protein, a subunit of the N-methyl-D-aspartate (NMDA) receptor involved in synaptic plasticity and learning/memory processes. This polyclonal antibody, generated in rabbits, is highly specific to human GRIN2B and has been validated for use in Western blot and immunohistochemistry applications.GRIN2B is a crucial component of the NMDA receptor complex, which plays a key role in excitatory neurotransmission and synaptic plasticity in the central nervous system. Dysregulation of GRIN2B has been implicated in various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease.
By targeting GRIN2B with this antibody, researchers can investigate the expression and localization of the protein in different cell types and brain regions, providing valuable insights into its function and potential implications in disease pathology.With its high specificity and versatility in various experimental techniques, the GRIN2B Antibody (PAC021517) is an essential tool for advancing our understanding of NMDA receptor function and its role in neurological disorders. Researchers in neuroscience, pharmacology, and neurology will benefit from using this antibody in their studies aimed at unraveling the complexities of synaptic transmission and neuronal communication.
Antibody Name:
Grin2b Antibody (PACO21517)
Antibody SKU:
PACO21517
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa.1250-1254(N-L-Y-D-I) derived from Human NMDANR2B Subunit.
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extract from T98G cells using NMDANR2B Subunit Antibody.
Background:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.Mol. Cell. Neurosci. 11:161-172(1998)
