The GRIN2A Polyclonal Antibody (CAB13863) is a valuable tool for researchers studying the GRIN2A protein, a subunit of the N-methyl-D-aspartate (NMDA) receptor involved in synaptic transmission and plasticity. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the GRIN2A protein, this antibody enables detection and analysis in a variety of cell types, making it an essential tool for neuroscience and neurological disorder research.The GRIN2A protein is known to play a crucial role in excitatory neurotransmission and synaptic plasticity, making it a key target for investigation in neurological disorders such as epilepsy, schizophrenia, and Alzheimer's disease.
Understanding the function and regulation of GRIN2A can provide insights into the underlying mechanisms of these conditions and potentially lead to the development of novel therapeutic strategies. The GRIN2A Polyclonal Antibody is a valuable resource for researchers aiming to unravel the complexities of NMDA receptor function in health and disease.
Product Name:
NMDAR2A Rabbit Polyclonal Antibody
SKU:
CAB13863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1130-1400 of human NMDAR2A (NP_000824.1).
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2903
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse brain, using NMDAR2A antibody (CAB13863) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
