The Grin1 Polyclonal Antibody (CAB7677) is a valuable tool for researchers studying the GluN1 subunit of the NMDA receptor, a key player in synaptic plasticity and learning and memory processes. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.The Grin1 antibody binds specifically to the GluN1 protein, allowing for precise detection and analysis in various cell types and tissues. Its high specificity and sensitivity make it an ideal choice for studies in neuroscience and neurobiology, as well as for investigating disorders related to NMDA receptor dysfunction, such as Alzheimer's disease, schizophrenia, and epilepsy.
By understanding the function and regulation of the GluN1 subunit using the Grin1 Polyclonal Antibody, researchers can gain valuable insights into synaptic transmission, neurological disorders, and potential therapeutic targets for treating these conditions.
Product Name:
NMDAR1 Rabbit Polyclonal Antibody
SKU:
CAB7677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 810-910 of human NMDAR1 (NP_015566.1).
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
2902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using NMDAR1 Rabbit pAb (CAB7677) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
