The GRIK4 Polyclonal Antibody (CAB13800) is a valuable tool for researchers studying the GRIK4 protein, a member of the glutamate receptor family known for its role in synaptic transmission and neuronal excitability. This antibody, generated from rabbits, exhibits high specificity and reactivity with human samples, making it a reliable option for Western blot applications.GRIK4, also known as GluR4, is a key player in regulating the excitatory neurotransmission mediated by glutamate receptors. Dysregulation of GRIK4 has been linked to various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease.
By targeting the GRIK4 protein, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.The GRIK4 Polyclonal Antibody enables precise detection and analysis of GRIK4 in different cell types, offering a versatile tool for studying its expression levels and localization in various experimental settings. Its applications extend beyond basic research into drug discovery and development, where understanding GRIK4 function could lead to the development of targeted therapies for neurological disorders.
Product Name:
GRIK4 Rabbit Polyclonal Antibody
SKU:
CAB13800
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human GRIK4 (NP_055434.2).
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRIK4 Rabbit pAb (CAB13800) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
