The Grid2ip Antibody (PAC045866) is a highly specific polyclonal antibody designed for research involving the Grid2ip protein. Grid2ip is a cell surface protein that plays a role in immune regulation, specifically in inhibiting immune responses. This antibody is raised in rabbits and is highly reactive with human samples, making it a valuable tool for detecting and analyzing Grid2ip in various cell types. It has been validated for use in Western blot applications, allowing for detailed studies in immunology and cancer research.Grid2ip, also known as an immune inhibitory protein, is crucial for maintaining immune homeostasis by regulating inflammation and inhibiting allergic reactions.
Its involvement in immune response modulation makes it a promising target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.By understanding the activity of Grid2ip, researchers can develop therapies that harness or modify immune function in these disease contexts, potentially leading to new treatment strategies and advancements in personalized medicine. Explore the possibilities with the Grid2ip Antibody (PAC045866) and unlock new insights into immune regulation and disease mechanisms.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45866 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO45866 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescent analysis of HepG2 cells using PACO45866 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
Synonyms:
Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1), GRID2IP
UniProt Protein Function:
GRID2IP: Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 7p22.1
UniProt Protein Details:
NCBI Summary:
Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]
