GRID2 Polyclonal Antibody (CAB19314)
- SKU:
- CAB19314
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
Description
Product Name: | GRID2 Polyclonal Antibody |
SKU: | CAB19314 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900-1007 of human GRID2 (NP_001501.2). |
Sequence: | IDLT PLDI DTLP TRQA LEQI SDFR NTHI TTTT FIPE QIQT LSRT LSAK AASG FTFG NVPE HRTG PFRH RAPN GGFF RSPI KTMS SIPY QPTP TLGL NLGN DPDR GTSI |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | GluD2; SCAR18; GRID2 |
Positive Sample: | Mouse brian |
Conjugate: | Unconjugated |
Cellular Localization: | dendritic spine, glutamatergic synapse, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse |
Calculated MW: | 113kDa |
Observed MW: | 113kDa |
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
Purification Method: | Affinity purification |
Gene ID: | 2895 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |