The GRID2 Polyclonal Antibody (CAB10020) is a valuable tool for research involving the GRID2 protein, a key player in synaptic transmission and plasticity. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.GRID2, a member of the glutamate receptor family, is essential for regulating synaptic strength and neural connectivity in the brain. Dysregulation of GRID2 function has been implicated in various neurological disorders, including ataxia and schizophrenia.
The GRID2 Polyclonal Antibody allows for precise detection and analysis of GRID2 expression levels in different cell types and tissues, providing valuable insight into its role in neuronal function and dysfunction.By studying the functions of GRID2, researchers can advance our understanding of neurological diseases and potentially develop targeted therapies to treat these conditions. The GRID2 Polyclonal Antibody is a reliable tool for investigating the complex mechanisms underlying synaptic transmission and plasticity, making it an essential component of neurobiology research.
Product Name:
GRID2 Polyclonal Antibody
SKU:
CAB19314
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900-1007 of human GRID2 (NP_001501.2).
dendritic spine, glutamatergic synapse, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Calculated MW:
113kDa
Observed MW:
113kDa
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
Purification Method:
Affinity purification
Gene ID:
2895
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brian, using GRID2 Rabbit pAb (CAB19314) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
