The GRIA4 Polyclonal Antibody (CAB1492) is a valuable tool for researchers investigating the role of the GRIA4 protein, a member of the AMPA receptor family involved in synaptic plasticity and excitatory neurotransmission. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.GRIA4, also known as Glutamate Ionotropic Receptor AMPA Type Subunit 4, is essential for proper neuronal communication and is implicated in various neurological disorders, including epilepsy and Alzheimer's disease. By targeting GRIA4 with this antibody, researchers can detect and study the protein's expression and localization in different cell types, providing insights into its function and potential therapeutic implications.
Given the critical role of GRIA4 in synaptic transmission and brain function, this polyclonal antibody is a valuable tool for studying neurological diseases and developing targeted therapies to modulate AMPA receptor activity. Its high reactivity and specificity make it an essential component of any research project focusing on GRIA4 and its implications in neurobiology.
Product Name:
GluR4/GluA4/GRIA4 Rabbit Polyclonal Antibody
SKU:
CAB1492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 254-433 of human GluR4/GluA4/GluR4/GluA4/GRIA4 (NP_001070712.1).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
Purification Method:
Affinity purification
Gene ID:
2893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GluR4/GluA4/GluR4/GluA4/GRIA4 antibody (CAB1492) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
