The GRIA3 Polyclonal Antibody (CAB13993) is a valuable tool for researchers studying the GRIA3 protein, a member of the glutamate receptor family involved in synaptic transmission and plasticity. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for Western blot applications. By targeting the GRIA3 protein, this antibody allows for the detection and analysis of GRIA3 expression in various cell types, enabling in-depth investigations into neurological and psychiatric disorders.
GRIA3, also known as AMPA receptor subunit 3, plays a crucial role in excitatory neurotransmission and synaptic plasticity, impacting cognitive functions such as learning and memory. Dysregulation of GRIA3 has been implicated in conditions like Alzheimer's disease, schizophrenia, and epilepsy, highlighting its importance as a potential therapeutic target. By elucidating the mechanisms underlying GRIA3 function, researchers can gain valuable insights into the pathophysiology of these disorders and identify novel strategies for treatment.
Product Name:
GRIA3 Rabbit Polyclonal Antibody
SKU:
CAB13993
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
Purification Method:
Affinity purification
Gene ID:
2892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GRIA3 antibody (CAB13993) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
