The GluR2 Rabbit Monoclonal Antibody is a powerful tool for researchers studying glutamate receptors, particularly the GluR2 subunit. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used in various applications such as Western blot and immunohistochemistry.The GluR2 subunit is a crucial component of AMPA receptors, playing a key role in neuronal signaling and plasticity. Dysregulation of GluR2 has been implicated in various neurological disorders, making it an important target of study in neuroscience research.By utilizing the GluR2 Rabbit Monoclonal Antibody, researchers can accurately detect and analyze the expression of GluR2 in different cell types and tissues.
This antibody enables precise investigation into the function and regulation of GluR2, providing valuable insights into synaptic transmission and excitotoxicity mechanisms.Overall, the GluR2 Rabbit Monoclonal Antibody is a reliable tool for scientists looking to deepen their understanding of glutamate receptor biology and its implications in neurological diseases. Its high specificity and sensitivity make it a valuable asset in unraveling the complex roles of GluR2 in neuronal function and dysfunction.
Product Name:
GluR2/GRIA2 Rabbit Monoclonal Antibody
SKU:
CAB11316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human GluR2/GRIA2 (P42262).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
2891
Clone Number:
ARC0572
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using GluR2/GRIA2 Rabbit mAb (CAB11316) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
