The GRIA1 Polyclonal Antibody (CAB1826) is a valuable tool for researchers studying the GRIA1 protein, which is a key component of the AMPA glutamate receptor complex in the central nervous system. This antibody, produced in rabbits, is highly specific to human GRIA1 and has been validated for use in Western blot applications.The AMPA glutamate receptor, which includes the GRIA1 subunit, plays a critical role in synaptic transmission and plasticity, making it essential for learning and memory processes. By targeting the GRIA1 protein, researchers can investigate the function and regulation of AMPA receptors in various neurological disorders, such as Alzheimer's disease, epilepsy, and schizophrenia.
The GRIA1 Polyclonal Antibody is a versatile tool for studying the role of AMPA receptors in neurobiology and drug development. Its high reactivity and specificity make it ideal for detecting GRIA1 in different cell types, providing valuable insights into the mechanisms underlying synaptic plasticity and potential therapeutic targets for neurological diseases.
Product Name:
GluR1/GRIA1 Rabbit Polyclonal Antibody
SKU:
CAB1826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 330-470 of human GluR1/GRIA1 (NP_000818.2).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2890
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using GluR1/GRIA1 Rabbit pAb (CAB1826) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
