The GRHPR Polyclonal Antibody (CAB17593) is a valuable tool for researchers studying the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR) and its role in various biological processes. This rabbit polyclonal antibody is highly specific to human GRHPR protein and has been validated for use in Western blot applications, allowing for accurate detection and analysis in different samples.GRHPR is an enzyme involved in the metabolism of glyoxylate and hydroxyproline, playing a crucial role in pathways such as the glyoxylate and dicarboxylate metabolism and the glycine, serine, and threonine metabolism.
Dysregulation of GRHPR has been implicated in diseases like primary hyperoxaluria, where mutations in the GRHPR gene lead to an accumulation of oxalate and subsequent kidney damage.By using the GRHPR Polyclonal Antibody, researchers can further explore the mechanisms and implications of GRHPR in health and disease, opening up avenues for potential therapeutic interventions in conditions related to oxalate metabolism and beyond. Its high reactivity and specificity make it an excellent choice for immunology and metabolic research studies.
Product Name:
GRHPR Rabbit Polyclonal Antibody
SKU:
CAB17593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-328 of human GRHPR (NP_036335.1).
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
Purification Method:
Affinity purification
Gene ID:
9380
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRHPR Rabbit pAb (CAB17593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
