The GRHL2 Polyclonal Antibody is a valuable tool for researchers studying the GRHL2 protein, a transcription factor known for its role in epithelial tissue development and cancer progression. This antibody, produced through immunization of rabbits, has been optimized for use in Western blot applications and is highly reactive with human samples.GRHL2, also known as grainyhead-like 2, is involved in the regulation of gene expression related to cell adhesion, epithelial barrier function, and epithelial-to-mesenchymal transition. Dysregulation of GRHL2 has been implicated in numerous cancers, making it a promising target for further investigation in cancer research.
By using the GRHL2 Polyclonal Antibody, researchers can detect and analyze GRHL2 protein expression in various cell types, providing valuable insights into its function and potential as a therapeutic target. This antibody is a valuable tool for studies in molecular biology, cancer biology, and developmental biology, offering the opportunity to deepen our understanding of GRHL2's role in health and disease.
Product Name:
GRHL2 Polyclonal Antibody
SKU:
CAB24468
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 110-210 of human GRHL2.
GRHL2; BOM; DFNA28; ECTDS; TFCP2L3; grainyhead-like protein 2 homolog
Positive Sample:
T-47D,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Nucleus.
Calculated MW:
69kDa/71kDa
Observed MW:
71kDa
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
Purification Method:
Affinity purification
Gene ID:
79977
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of T-47D, using GRHL2 Rabbit pAb (CAB24468) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
