The GRB2 Rabbit Monoclonal Antibody (CAB19059) is a powerful tool for researchers studying the GRB2 protein, a key signaling molecule involved in cell growth and differentiation. This antibody, raised in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for Western blot applications.GRB2 is a critical adaptor protein that plays a central role in numerous signaling pathways, including those involved in cell proliferation, differentiation, and survival. Dysregulation of GRB2 signaling has been implicated in various diseases, including cancer, making it an attractive target for therapeutic interventions.
By utilizing the GRB2 Rabbit Monoclonal Antibody, researchers can effectively detect and analyze GRB2 protein levels in various cell types, providing valuable insights into its function and dysregulation in disease states. This antibody is an essential tool for studies exploring the role of GRB2 in cancer, cell signaling, and other cellular processes, ultimately contributing to the development of novel therapeutic strategies.
Product Name:
GRB2 Rabbit Monoclonal Antibody
SKU:
CAB19059
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 118-217 of human GRB2 (P62993).
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2885
Clone Number:
ARC0430
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRB2 Rabbit mAb (CAB19059) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
