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GRB2 Rabbit Polyclonal Antibody (CAB5689)

SKU:
CAB5689
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-GRB2 Antibody CAB5689
  • Immunology Antibodies 2 Anti-GRB2 Antibody CAB5689
  • Immunology Antibodies 2 Anti-GRB2 Antibody CAB5689
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:GRB2 Rabbit Polyclonal Antibody
SKU:CAB5689
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GRB2 (NP_002077.1).
Sequence:MEAI AKYD FKAT ADDE LSFK RGDI LKVL NEEC DQNW YKAE LNGK DGFI PKNY IEMK PHPW FFGK IPRA KAEE MLSK QRHD GAFL IRES ESAP GDFS LSVK FGND VQHF KVLR DGAG KYFL WVVK FNSL NELV DYHR STSV SRNQ QIFL RDIE QVPQ QPTY VQAL FDFD PQED GELG FRRG DFIH VMDN SDPN WWKG ACHG QTGM FPRN YVTP VNRN V
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100
Synonyms:ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; GRB2
Positive Sample:SW620,Raji,BT-474,HepG2,Mouse heart
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endosome, Golgi apparatus, Nucleus.
Calculated MW:25kDa
Observed MW:33kDa

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:2885
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using GRB2 antibody (CAB5689) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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