Anti-GRB14 Antibody (CAB2742)
- SKU:
- CAB2742
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-GRB14 Antibody (CAB2742)
The GRB14 Polyclonal Antibody (CAB2742) is a valuable tool for researchers studying GRB14, a key protein involved in insulin signaling and metabolic regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the GRB14 protein, this antibody allows for reliable detection and analysis in a variety of cell types, making it an essential component for studies in diabetes, obesity, and related metabolic disorders.GRB14, also known as growth factor receptor-bound protein 14, is a critical regulator of insulin signaling pathways and glucose metabolism. Its role in modulating insulin sensitivity and energy balance highlights its potential as a therapeutic target for metabolic disorders such as type 2 diabetes.
Research into the function and regulation of GRB14 is essential for uncovering potential treatment strategies that could improve the management of these prevalent diseases.Overall, the GRB14 Polyclonal Antibody (CAB2742) offers researchers a precise and reliable tool for investigating the role of GRB14 in metabolic health and disease. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of insulin signaling and identifying novel therapeutic opportunities for metabolic disorders.
| Antibody Name: | Anti-GRB14 Antibody |
| Antibody SKU: | CAB2742 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human GRB14 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:25 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human fetal intestine |
| Immunogen: | Recombinant protein of human GRB14 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2888 |
| Uniprot: | Q14449 |
| Cellular Location: | Cytoplasm, Endosome membrane, Golgi apparatus membrane, Peripheral membrane protein |
| Calculated MW: | 51kDa/60kDa |
| Observed MW: | 61kDa |
| Synonyms: | GRB14 |
| Background: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GRB14: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q22-q24 Cellular Component: Golgi membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:SH3/SH2 adaptor activity Biological Process: positive regulation of signal transduction; signal transduction; blood coagulation; leukocyte migration |
| NCBI Summary: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q14449 |
| NCBI GenInfo Identifier: | 59802920 |
| NCBI Gene ID: | 2888 |
| NCBI Accession: | Q14449.2 |
| UniProt Secondary Accession: | Q14449,Q7Z6I1, B7Z7F9, |
| UniProt Related Accession: | Q14449 |
| Molecular Weight: | 540 |
| NCBI Full Name: | Growth factor receptor-bound protein 14 |
| NCBI Synonym Full Names: | growth factor receptor-bound protein 14 |
| NCBI Official Symbol: | GRB14Â Â |
| NCBI Protein Information: | growth factor receptor-bound protein 14; GRB14 adapter protein |
| UniProt Protein Name: | Growth factor receptor-bound protein 14 |
| UniProt Synonym Protein Names: | GRB14 adapter protein |
| Protein Family: | Growth factor receptor-bound protein |
| UniProt Gene Name: | GRB14Â Â |
| UniProt Entry Name: | GRB14_HUMAN |
 | Western blot analysis of extracts of human fetal intestine, using GRB14 antibody (CAB2742). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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