The GRB10 Polyclonal Antibody (CAB0634) is a valuable tool for researchers investigating the GRB10 protein, which plays a key role in signal transduction pathways involved in growth and development. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for experiments such as Western blotting.GRB10 is a crucial adaptor protein involved in various cellular processes, including cell growth, differentiation, and metabolism. Dysregulation of GRB10 has been linked to diseases such as cancer, diabetes, and obesity, making it a potential therapeutic target.
By using the GRB10 Polyclonal Antibody, researchers can study the expression levels and localization of GRB10 in different cell types, providing valuable insights into its function and potential implications in disease pathogenesis.Overall, the GRB10 Polyclonal Antibody is a versatile tool for researchers interested in exploring the role of GRB10 in health and disease. Its high reactivity and specificity make it a reliable option for detecting and analyzing GRB10 protein levels, facilitating advancements in the fields of molecular biology, cell biology, and disease research.
Product Name:
GRB10 Rabbit Polyclonal Antibody
SKU:
CAB0634
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GRB10 (NP_005302.3).
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
2887
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using GRB10 antibody (CAB0634) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.